A subject breathes in from a balloon filled with 500 mL of a test gas such as helium (mixed with oxygen) that is not taken up by or liberated from the pulmonary capillary blood. The anatomic dead space is illustrated in Figure 3–7. During exercise, the FRC may be lower than the relaxation volume because of active contraction of the expiratory muscles. Either or both of these may occur in babies, who have higher FRCs than would be predicted from the great inward elastic recoil of their lungs and the small outward recoil of their chest walls. The FRC may be greater than the relaxation volume if the next inspiration occurs before the relaxation volume is reached, either because of high breathing rates or high resistance to expiratory airflow in the larynx or peripheral airways, or because of active contraction of the inspiratory muscles at end expiration. Thus, the lung volume at which the inward elastic recoil of the lungs is equal and opposite to the outward elastic recoil of the chest wall is sometimes referred to as the relaxation volume of the respiratory system. However, the respiratory muscles may have significant tone at the FRC, and in certain circumstances, the FRC may be greater than or even less than the lung volume of the totally relaxed respiratory system. Predicts the effects of changes in pulmonary mechanics on the closing volume.Defines the closing volume and explains how it can be demonstrated.Predicts the effects of changes in lung volume, aging, and disease processes on the regional distribution of alveolar ventilation.Describes the regional differences in alveolar ventilation found in the normal lung and explains these differences.Predicts the effects of alterations of alveolar ventilation on alveolar carbon dioxide and oxygen levels.Defines physiologic and alveolar dead space and understands their determination.Understands the measurement of the anatomic dead space and the determination of alveolar ventilation.Defines anatomic dead space and relates the anatomic dead space and the tidal volume to alveolar ventilation.Predicts the effects of alterations in lung and chest wall mechanics, due to normal or pathologic processes, on the lung volumes.
Defines the standard lung volumes and understands their measurement.
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